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Phosphorothioate Bonds Modifications

Phosphorothioate Bond

The phosphorothioate (PS) bond substitutes a sulfur atom for a non-bridging oxygen in the phosphate backbone of an oligo. This modification renders the internucleotide linkage resistant to nuclease degradation. Phosphorothioate bonds can be introduced between the last 3-5 nucleotides at the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. Including phosphorothioate bonds throughout the entire oligo will help reduce attack by endonucleases as well.

Phosphorothioate Bond Entry
Bond NameSymbolExample
Phosphorothioated DNA bases _* e.g. A*
Phosphorothioated RNA bases r_* e.g. rA*
Phosphorothioated 2' O-methyl bases m_* e.g. mA*
Phosphorothioated LNA bases +_* e.g. +A*
Pricing Details (price per bond)
Product Pricing Order
100 nmole DNA Oligo$3.50 USDAdd to Order
250 nmole DNA Oligo$3.50 USDAdd to Order
1 umole DNA Oligo$5.00 USDAdd to Order
5 umole DNA Oligo$20.00 USDAdd to Order
10 umole DNA Oligo$30.00 USDAdd to Order
100 nmole RNA Oligo$3.50 USDAdd to Order
250 nmole RNA Oligo$3.50 USDAdd to Order
1 umole RNA Oligo$5.00 USDAdd to Order
5 umole RNA Oligo$20.00 USDAdd to Order
10 umole RNA Oligo$30.00 USDAdd to Order

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